Lactase persistence genotypes and malaria susceptibility in Fulani of Mali
نویسندگان
چکیده
منابع مشابه
Fc gamma Receptor IIa-H131R Polymorphism and Malaria Susceptibility in Sympatric Ethnic Groups, Fulani and Dogon of Mali
It has been previously shown that there are some interethnic differences in susceptibility to malaria between two sympatric ethnic groups of Mali, the Fulani and the Dogon. The lower susceptibility to Plasmodium falciparum malaria seen in the Fulani has not been fully explained by genetic polymorphisms previously known to be associated with malaria resistance, including haemoglobin S (HbS), hae...
متن کاملEvolution of Lactase Persistence
Though humans are known to lose lactase ability post-weaning, some people maintain lactase production into adulthood, a condition known as lactase persistence. Global distribution patterns of lactase persistency are inconsistent; the condition is much more prevalent in some populations than others. Using results across independent studies, the existence of such a phenomenon can be attributed to...
متن کاملInteraction between environment, nutrient-derived metabolites and immunity: A possible role in malaria susceptibility/resistance in Fulani and Dogon of Mali
The role of some nutrient-derived metabolites on the innate and adaptive immune responses is now established. Global research approach investigating the interplay between environment, lifestyle and the host's immune responses is crucial in the understanding of malaria susceptibility. Advanced Glycation end products (AGE), which are food-derived metabolites result from the link between reducing ...
متن کاملMolecular Genetics of Lactase Persistence
This thesis is based on the following original articles, which are referred to in the text by their Roman numerals. In addition, some unpublished data are presented Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene. Identification of a variant associated with adult-type hypolactasia. Transcriptional regul...
متن کاملGenetics of lactase persistence and lactose intolerance.
The enzyme lactase that is located in the villus enterocytes of the small intestine is responsible for digestion of lactose in milk. Lactase activity is high and vital during infancy, but in most mammals, including most humans, lactase activity declines after the weaning phase. In other healthy humans, lactase activity persists at a high level throughout adult life, enabling them to digest lact...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2011
ISSN: 1475-2875
DOI: 10.1186/1475-2875-10-9